MyResume

About Me

I am Rex Devasahayam Arokia Balaya, a Ph.D. holder from Yenepoya (Deemed to be University), Mangalore, India. As an Assistant Professor, my focus has been on studying interleukins and their role in cellular signaling related to inflammatory diseases. Specifically, I employ a quantitative phosphoproteomic approach to investigate the temporal dynamics of IL-33-mediated signaling in monocytes.

Post Doctoral Research Fellow

My expertise encompasses various aspects of proteomics, including sample preparation, instrumentation, data interpretation, and unraveling signaling pathways

D.O.B: 17/10/1986
Phone: +91 9035056486
City: Rochester, Minnesota

Degree: Ph.D.
PhEmailone: rexprem@gmail.com
Freelance: Available

Currently, I am dedicated to developing CRISPR/Cas9 knockout models in both cell lines and mice at the Department of Laboratory Medicine and Pathology, Center for Individualized Medicine, Mayo Clinic in Rochester, Minnesota, USA. Additionally, I am involved in mass spectrometry-based multi-omics analysis and single-cell proteomics to comprehend the molecular basis of various diseases, including multiple myeloma, for the development of novel diagnostic biomarkers and potential new therapeutics.

Facts

Throughout my academic and professional journey, I have been recognized for my contributions through publications, awards, and other notable achievements

Publications

Projects

Patents

Awards

Skills

My skill page showcases a wide array of proficiencies, including expertise in proteomics sample preparation, advanced instrumentation, data interpretation, and the study of signaling pathways

R Package 50%

Python 50%

Proteome Discoverer 50%

PathVisio 90%

MaxQuant, 55%

Cytoscape80%

Resume

I have achieved academic excellence in the field of Biochemistry, with a Ph.D. from Yenepoya (Deemed to be University), along with an M.Phil., M.Sc., Diploma, and B.Sc. from renowned institutions in India

Sumary

Rex Devasahayam Arokia Balaya

A Ph.D. holder from Yenepoya (Deemed to be University), Mangalore, India. As an Assistant Professor, my focus has been on studying interleukins and their role in cellular signaling related to inflammatory diseases

Rochester, Minnesota
phone
rexprem@gmail.com

Education

Ph.D. in Biochemistry

2017 - 2022

Yenepoya (Deemed to be University)Mangalore, Karnataka, India

M.Phil. in Biochemistry

2010 - 2012

P.S.G College of Arts and Science, Bharathiar University,Coimbatore, Tamil Nadu, India

M.Sc. in Biochemistry

2007 - 2009

J. J. College of Arts and Science, Bharathidasan University,Trichy, Tamil Nadu, India

Diploma in Bioinformatics

2007 - 2008

J. J. College of Arts and Science, Bharathidasan University,Trichy, Tamil Nadu, India

B.Sc in Biochemistry

2004 - 2007

Yadava College, Madurai Kamaraj university Madurai, Tamil Nadu, India

Professional Experience

Post Doctoral Research Fellow

2023 - Present

Department of Laboratory Medicine and Pathology

Center for Individualized Medicine at Mayo Clinic in Rochester, Minnesota, USA

Assistant Professor

2022 - 2023

Centre for Integrative Omics Data Science

Trained 18 students on proteomics, metabolomics and signaling pathways (Wet lab experiments and data analysis)
developed a tool for proteomics (ProteoArk) and metabolomics data analysis

Ph.D. student

2016-2022

Yenepoya (Deemed to be University)

Project title: "Spatiotemporal influence of Interleukin-1 family cytokine in cellular signal transduction signaling pathways"
Combained phosphoproteomics, western blot, and RT-PCR analysis to study signaling dynamics of IL-33 mediated signaling in monocytes using TMT labeling-based quantitation

Project fellow

2015-2016

ICMR- National Institute of Traditional Medicine, Belagavi, Karnataka, India

Project title: “Understanding the Molecular Mechanism of Mitochondrial Division in Malaria Parasites”
Performed molecular biology experiments including primer designing, Infusion cloning, PCR amplification, knock-down and knock out (CRISPR-Cas9) studies

Project Fellow

2014-2015

PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India

Project title: "A Study of HDL Function and Proteomics"
A Novel Method of Evaluating Dyslipidemia treatment Isolated monocytes from PBMCs and cell culture of macrophage cell lines
Standardized flow cytometric analysis of CD4 and CD8 count in blood samples

Technical Skills (Cell and Molecular Biology)

With a strong foundation in cell and molecular biology, I possess comprehensive technical skills and expertise in studying the intricate mechanisms and processes that govern cellular functions at the molecular level

Proteomics and Protein Biochemistry

Enrichment of phosphoproteome, acetylome and succinylome using antibodies
Western Blotting

Proteogenomics

Identification of novel events such as variant peptides from unassigned spectra.
Integrative Genome Viewer (IGV), BLASTp (NCBI) and ClustalW tools were used for this method

Signaling pathways

Literature curation and bioinformatic analysis of pathway related data

Molecular biology and cell
culture

Hands on experience in primary and cancer cell lines
Gene editing techniques including CRISPR- Cas 9 (Plasmodium falciparum 3D7)

Proteomics Software

Proteome Discoverer, Skyline, MaxQuant, Xcalibur 4.0

Developed a tool for proteomics : ProteoArk

LC-MS

Handling, maintenance and calibration (Orbitrap Fusion)

Top 10 Publications

Terlouw, Barbara; Blin, Kai; Navarro-Muñoz, Jorge C.; Avalon, Nicole; Chevrette, Marc G.; Egbert, Rex, D. A. B; Linington, Roger; Weber, Tilmann; Medema, Marnix. (2022). MIBiG 3.0: A community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Research (Impact factor- 19.16).

Ostaszewski, M., Niarakis, A., Mazein, A., Kuperstein, I., Phair, R., Orta, Resendiz A., …, Rex, D. A. B., …, Kitano, H., Barillot, E., Au.ray, C., Balling, R., Schneider, R. and COVID-19 Disease Map Community. (2021). COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms. Molecular Systems Biology. 2021 Oct;17(10): e10387. PMID: 34664389. (Impact factor 13.068)

Rex, D. A. B., Subbannayya, Y., Modi, P. K., Palollathil, A., Gopalakrishnan, L., Bhandary, Y. P., Prasad, T. S. K. and Pinto, S. M. (2021). Temporal quantitative phosphoproteomics profiling of Interleukin-33 signaling network reveals unique modulators of monocyte activation. Cells. Jan 1;11(1):138. PMID: 35011700. (Impact factor 7.6)

Shaikh, S., Najar, M. A., Prabhu, A., Rex, D. A. B., Chanderasekaran, J., Behera, S., Modi, P., Prasad, T. S. K. and Bhandary, Y. (2021). The unique molecular targets associated anti-oxidant and anti-fibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach. BioFactors. PMID: 33864298. (Impact factor 6.4)

Kumar, S., Rex, D. A. B., Saptami, K., Raju, R., T. S. Keshava Prasad., Kandasamy, R. K. (2023). Computational Tools for Exploring Peptide-Membrane Interactions in Gram-Positive Bacteria. Computational and Structural Biotechnology Journal. (Impact factor: 6.15). (Shared first author and corresponding author)

Anam, E. Z*., Kumari, G*., Mukherjee, S*., Rex, D.A.B*., Sah, RK., Chaurasiya, A., Singhal, J., Singh, N., Kaushik, S., Prasad, T. S. K., Pati, S., Ranganathan, A., Singh, S. (2022). Complementary crosstalk between palmitoylation and phosphorylation events in MTIP regulate its role during Plasmodium falciparum invasion. Frontiers in Cellular and Infection Microbiology. (Impact Factor: 6.073). * Shared first author

Rex, D. A. B., Agarwal, N., Prasad, T. S. K., Kandasamy, R. K., Subbannayya, Y. and Pinto, S. M. (2020). A comprehensive pathway map of IL-18-mediated signalling. Journal of Cell Communication and Signaling. Jun;14(2):257-266. PMID: 31863285. (Impact factor: 5.9)

Dagamajalu, S., Rex, D. A. B., Suchitha G. P., Rai, B. A., Rainey, J. K., and Prasad, T. S. K. (2021). The network map of Elabela signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2, 1-0. PMID: 34339006. (Impact factor: 5.9)

Rex, D. A. B., Suchitha G. P., Palollathil, A., Kanichery, A., Prasad, T. S. K. and Dagamajalu, S. (2022). The network map of Urotensin-II mediated signaling pathway in physiological and pathological conditions. Journal of Cell Communication and Signaling. (Impact factor: 5.9)

Rex, D. A. B., K. Deepak, K., Vaid, N., Dagamajalu, S., Kandasamy, R. K., Flo, T. H. and Prasad, T. S. K. (2021). A modular map of Bradykinin-mediated inflammatory signaling network. Journal of Cell Communication and Signaling. Oct 29:1–10. PMID: 34714516. (Impact factor 5.9)

Publications

In the realm of scientific publications, my research findings have been recognized and showcased through a diverse range of articles, reflecting my expertise and contributions to the field

1. Sanjeev, D., Dagamajalu, S*., Shaji, V., George, Subbannayya, Y., M., Prasad, T. S. K., Raju, R*., Rex, D. A. B*. (2023). A network map of MSP signaling pathway. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)
2. Upadhyay, S. S., Rex, D. A. B*., Parate, S. S., Dagamajalu, S., Prasad, T. S. K*., Shetty, R*., Raju, R*. (2023). An assembly of TROP2-mediated signaling events. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)
3. Chandrasekaran, J., Parasuraman, P., Krishnan, S., Rex, D. A. B., Kunjiappan, S. (2023). Prospects for repurposing FDA-approved medications as Omicron spike/ACE-2 protein complex disruptors. Journal of Research in Pharmacy.
4. Suchitha G. P., Rex, D.A.B*., Raju, R., Prasad, T.K., Dagamajalu, S. A. (2023). network map of Cytoskeleton-associated protein 4 (CKAP4)-mediated signaling pathway in cancer. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)
5. Kumar, S., Rex, D. A. B., Saptami, K., Raju, R., T. S. Keshava Prasad., Kandasamy, R. K. (2023). Computational Tools for Exploring Peptide-Membrane Interactions in Gram-Positive Bacteria. Computational and Structural Biotechnology Journal. (Impact factor: 6.15). (Shared first author and corresponding author)
6. Rex, D.A.B., Jaikanth, C., Saptami, K., Modi, P., Shobha, D., Raju, R., Prasad, T.K., Computational design of novel Calcium/Calmodulin-Dependent protein kinase kinase 2 (CAMKK2) inhibitors. Journal of Biomolecular Structure and Dynamics. (Impact factor: 5.235) (Shared first author and corresponding author)
7. Mol, P., Rex, D. A. B., Dagamajalu, S., Babu, S., Chandrasekaran, P., Raghuvan., Suresh, S., Ravishankara, N., Raj, H. A., Nair, B., Modi, P. K., Madevan, A., Prasad, T. S. K., Raju, R. (2022). A network map of GDNF/RET signaling pathway in physiological and pathological conditions. Journal of Cell Communication and Signaling. (Impact factor 5.9) (Shared corresponding author)
8. Dagamajalu, S*., Rex, D. A. B*., Suchitha G. P., Rai, B. A., Raju, R., Prasad, T. S. K.(2022). A network map of Discoidin Domain Receptor 1 (DDR1)-mediated signaling in pathological conditions. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared first author and Shared corresponding author)
9. Rex, D. A. B*., Kanekar, S*., Chanderasekaran, J., Rekha, P. D. Pleotropic potential of quorum sensing mediated N-acyl homoserine lactones (AHLs) at the LasR and RhlR receptors of Pseudomonas aeruginosa. Molecular Diversity. (Impact factor: 3.364) (Shared first author)
10. Terlouw, Barbara; Blin, Kai; Navarro-Muñoz, Jorge C.; Avalon, Nicole; Chevrette, Marc G.; Egbert, Rex, D. A. B; Linington, Roger; Weber, Tilmann; Medema, Marnix. (2022). MIBiG 3.0: A community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Research (Impact factor- 19.16).
11. Kumari, G., Rex, D. A. B., Goswami, S., Mukherjee, S., Biswas, S., Maurya, P., Jain, R., Garg, S., Prasad, T. S. K., Pati, S., Ramalingam, S., Mohandas, N., Singh, S. (2022). Dynamic palmitoylation of Red cell membrane proteins governs susceptibility to invasion by malarial parasite. ACS Infectious Diseases. (Impact Factor: 5.578)
12. Anam, E. Z*., Kumari, G*., Mukherjee, S*., Rex, D.A.B*., Sah, RK., Chaurasiya, A., Singhal, J., Singh, N., Kaushik, S., Prasad, T. S. K., Pati, S., Ranganathan, A., Singh, S. (2022). Complementary crosstalk between palmitoylation and phosphorylation events in MTIP regulate its role during Plasmodium falciparum invasion. Frontiers in Cellular and Infection Microbiology. (Impact Factor: 6.073). * Shared first author
13. Rex, D. A. B., Dagamajalu, S., Gouda, M., Suchitha G. P., Chanderasekaran, J., Raju, R., Prasad, T. S. K., and Bhandary, Y. P (2022). A comprehensive network map of IL-17A signaling pathway. Journal of Cell Communication and Signaling. (Impact factor 5.9) (First author and Shared corresponding author)
14. Rex, D. A. B., Prasad, T. S. K., Kandasamy, R. K. (2022). Revisiting Regulated Cell Death Responses in Viral Infection. International Journal of Molecular Sciences. (Impact Factor: 6.208)
15. Phukan, S., Sarma, A., Rex, D. A. B., Rai, B. A., Prasad, T. S. K., Madanan, M. G. (2022). Unique post-translational modification sites for acetylation, glutarylation, and phosphorylation are found specific to the proteins partitioned in the Triton X-114 fractions of Leptospira. ACS-Omega. (Impact factor: 4.132)
16. Kanekar, S., Rex, D. A. B., Chanderasekaran, J., Rekha, P. D. (2022). Competitive interaction of thymol with cviR inhibits quorum sensing and associated biofilm formation in Chromobacterium violaceum. International Microbiology. (Impact factor: 3.097)
17. Rex, D. A. B., Vaid, N., K. Deepak, K., Dagamajalu, S., Prasad, T. S. K. (2022). A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases. Molecular Biology Reports. (Impact factor: 2.741)
18. Rex, D. A. B., Chanderasekaran, J., Rai, B. A., Phukan, S., Sarma, A., Prasad, T. S. K., Madanan, M. G. (2022). Leptospira and Leptospirosis: New systems science insights on proteome, posttranslational modifications and pathogen-host interaction. OMICS: A Journal of Integrative Biology. (Impact factor: 3.978)
19. Rex, D. A. B., Patil, A. H., Modi, P. K., Kandiyil, M. K., Tanneru, N., Pinto, S. M., Tanneru, N., Kasaragod, S., Sijwali, P. S., Prasad, T. S. K. (2022). Dissecting Plasmodium yoelii pathobiology: proteomics approaches for decoding novel translational and post-translational modifications. ACS Omega. (Impact factor: 4.132)
20. Rex, D. A. B., Suchitha G. P., Palollathil, A., Kanichery, A., Prasad, T. S. K. and Dagamajalu, S. (2022). The network map of Urotensin-II mediated signaling pathway in physiological and pathological conditions. Journal of Cell Communication and Signaling. (Impact factor: 5.9)
21. Rex, D. A. B., Subbannayya, Y., Modi, P. K., Palollathil, A., Gopalakrishnan, L., Bhandary, Y. P., Prasad, T. S. K. and Pinto, S. M. (2021). Temporal quantitative phosphoproteomics profiling of Interleukin-33 signaling network reveals unique modulators of monocyte activation. Cells. Jan 1;11(1):138. PMID: 35011700. (Impact factor 7.6)
22. Ostaszewski, M., Niarakis, A., Mazein, A., Kuperstein, I., Phair, R., Orta, Resendiz A., …, Rex, D. A. B., …, Kitano, H., Barillot, E., Au.ray, C., Balling, R., Schneider, R. and COVID-19 Disease Map Community. (2021). COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms. Molecular Systems Biology. 2021 Oct;17(10): e10387. PMID: 34664389. (Impact factor 13.068)
23. Shaikh, S., Najar, M. A., Prabhu, A., Rex, D. A. B., Chanderasekaran, J., Behera, S., Modi, P., Prasad, T. S. K. and Bhandary, Y. (2021). The unique molecular targets associated anti-oxidant and anti-fibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach. BioFactors. PMID: 33864298. (Impact factor 6.4)
24. Rex, D. A. B., Dagamajalu, S., Raju, R., Kandasamy, R. K. and Prasad, T. S. K. (2021). SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanism in COVID-19. Journal of Cell Communication and Signaling. 15, 601-608. PMID: 34181169. (Impact factor 5.9)
25. Sarma, A., Dhandapani, G., Rex, D. A. B., Thoduvayil, S., Phukan, H., Kumar, M., Pinto, S. M., Prasad, T. S. K. and Madanan, M. G. (2021). Extracellular proteome analysis shows the abundance of Histidine kinase sensor protein (LIC_11528), DNA helicase (LIC_11624), Putative lipoprotein (LIC_10713) and Peptidase C39 domain protein (LIC_10511) in Leptospira interrogans grown in EMJH medium. Pathogens. Jul 6;10(7):852. PMID:34358002. (Impact factor: 4.531)
26. Rex, D. A. B., Kumar, S. T. A., Rai, B. A., Kotimoole, C. N., Modi, P. K. and Prasad, T. S. K. (2021). Novel Post- translational Modifications and Molecular Substrates in Glioma Identified by Bioinformatics. OMICS: A Journal of Integrative Biology. 25, 463-473. PMID: 34227895. (Impact factor: 3.978)
27. Rex, D. A. B., K. Deepak, K., Vaid, N., Dagamajalu, S., Kandasamy, R. K., Flo, T. H. and Prasad, T. S. K. (2021). A modular map of Bradykinin-mediated inflammatory signaling network. Journal of Cell Communication and Signaling. Oct 29:1–10. PMID: 34714516. (Impact factor 5.9)
28. Dagamajalu, S., Vijayakumar, M., Shetty, R., Rex, D. A. B., Narayana Kotimoole, C. and Prasad, T. S. K. (2020). Proteogenomic examination of esophageal squamous cell carcinoma (ESCC): new lines of inquiry. Expert Review of Proteomics. Sep;17(9):649-662. PMID: 33151123. (Impact factor: 4.2)
29. Gouda, M., Rex D. A. B., Sindu, P. E. S., Modi, P. K., Chanderasekaran, J. and Bhandary, Y. P. (2020). Proteomics analysis revealed the importance of inflammation-mediated downstream pathways and the protective role of curcumin during bleomycin-induced pulmonary fibrosis in C57BL/6 mice. Journal of Proteome Research. Aug 7;19(8):2950-2963. PMID: 32618472. (Impact factor: 5.3)
30. Thoduvayil, S., Dhandapani, G., Brahma, R., Rex, D. A. B., Mangalaparthi, K. K., Patel, K., Kumar, M., Tennyson, J., Satheeshkumar, P. K., Kulkarni, A., Pinto, S. M., Prasad, T. S. K. and Madanan, M. G. (2020). Triton X-114 fractionated subcellular proteome of Leptospira interrogans shows selective enrichment of pathogenic and outer membrane proteins in the detergent fraction. Proteomics. Oct;20(19-20): e2000170. PMID: 32846045. (Impact factor: 5.39)
31. Rex, D. A. B., Agarwal, N., Prasad, T. S. K., Kandasamy, R. K., Subbannayya, Y. and Pinto, S. M. (2020). A comprehensive pathway map of IL-18-mediated signalling. Journal of Cell Communication and Signaling. Jun;14(2):257-266. PMID: 31863285. (Impact factor: 5.9)
32. Antil, N., Kumar, M., Behera, S. K., Arefan, M., Kotimoole, C. N., Rex, D. A. B. and Prasad, T. S. K. (2021). Unraveling Toxoplasma gondii GT strain virulence and new protein-coding genes with proteogenomic analyses. OMICS: A Journal of Integrative Biology. 25, 591-604. PMID: 34468217. (Impact factor: 3.973)
33. Dagamajalu, S., Rex, D. A. B., Suchitha G. P., Rai, B. A., Rainey, J. K., and Prasad, T. S. K. (2021). The network map of Elabela signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2, 1-0. PMID: 34339006. (Impact factor: 5.9)
34. Aravind, A., Palollathil, A., Rex, D. A. B., Kumar, K. M. K., Vijayakumar, M., Shetty, R., Codi, J. A. K., Prasad, T. S. K. and Raju, R. (2021). A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor functions. Journal of Cell Communication and Signaling. PMID: 34196939. (Impact factor: 5.9)
35. Deolankar S. C., Patil, A. H., Rex, D. A. B., Subba, P., Mahadevan, A. and Prasad, T. S. K. (2021). Mapping Post-Translational Modifications in Brain Regions in Alzheimer’s Disease Using Proteomics Data Mining. OMICS: A Journal of Integrative Biology. 25, 525-536. PMID: 34255573. (Impact factor: 3.973)
36. Rex, D. A. B., Kumar, S. T. A., Modi, P. K. and Prasad, T. S. K. (2021). Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe or Promising Molecular Target? OMICS: A Journal of Integrative Biology. 25, 408-416. PMID: 34191617. (Impact factor: 3.973)
37. Najar, M. A., Rex, D. A. B., Modi, P. K., Agarwal, N., Dagamajalu, S., Karthikkeyan, G., Vijayakumar, M., Chatterjee, A., Sankar, A. and Prasad, T. S. K. (2021). A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. Journal of Cell Communication and Signaling.15, 283–290. PMID: 33136287. (Impact factor: 5.9)
38. Dagamajalu, S*., Rex, D. A. B*., Gopalakrishnan, L., Karthikkeyan, G., Gurtoo. S., Modi, P. K., Mohanty, V., Rahiman, M., Soman, S., Raju, R., Tiwari, V. and Prasad, T. S. K. (2021). A network map of endothelin mediated signaling pathway. Journal of Cell Communication and Signaling. 15, 277-282. PMID: 32915369. (Impact factor: 5.9). * Shared first author
39. Dagamajalu, S*., Rex, D. A. B*., Palollathil, A., Shetty, R., Bhat, G., Cheung, L.W.T. and Prasad, T. S. K. (2021). A pathway map of AXL receptor-mediated signaling network. Journal of Cell Communication and Signaling. 15, 143-148. PMID: 32829427. (Impact factor: 5.9). * Shared first author
40. Dagamajalu, S*., Rex, D. A. B*., Philem, P. D., Rainey, J. K., and Prasad, T. S. K. (2021). A network map of apelin- mediated signaling. Journal of cell communication and signaling. 16, 137-143. PMID: 33797707. (Impact factor: 5.9). * Shared first author
41. Kulkarni, S., Abdulla, R., Jose, M., Adyanthaya, S., Rex, D.A.B., Patil, A. H., Pinto, S.M. and Subbannayya, Y. (2019). Omics data-driven analysis identi.es laminin-integrin-mediated signaling pathway as a determinant for cell di.erentiation in oral squamous cell carcinoma. Indian Journal of Pathology and Microbiology. 62, 529-536. PMID: 31611435.
42. Advani, J., Verma, R., Chatterjee, O., Rex, D. A. B., Najar, M. A., Ravishankara, N., Suresh, S., Pachori, P. K., Gupta, U. D., Pinto, S. M., Chauhan, D. S., Tripathy, S. P., Gowda, H. and Prasad, T. S. K. (2019). Rise of clinical microbial proteogenomics: A multi-omics approach to non-tuberculous mycobacterium – the case of Mycobacterium abscessus UC22. OMICS: A Journal of Integrative Biology. 23, 1-16. PMID: 30207826. (Impact factor: 3.973)
43. Pinto, S. M., Subbannayya, Y., Rex, D. A. B., Raju, R., Chatterjee, O., Advani, J., Radhakrishnan, A., Prasad, T. S. K., Wani, M. R. and Pandey, A. (2018). A network map of IL-33 signaling pathway. Journal of Cell Communication and Signaling. 12, 615-624. PMID: 29705949. (Impact factor: 5.9)
44. Rex, D. A. B., Kumar, RR. (2014). The Role of Nanotechnology in Targeting Carcinogens-A Comparison on Synthesis of Gold and Zinc Nanoparticles. Journal of Biomaterials and Tissue Engineering. 4 (8), 591-599. (Impact factor: 0.144)
45. Rex, D. A. B. (2014). Selenium enriched mushrooms as a food supplement for prevention of neurodegenerative diseases. Int J Pharm Pharm Sci, 6, 1-2.
46. Karthikeyan, A., Siva, G., Sujitha, SP., Rex, D. A. B., Chidambaranathan, N. (2008). Antihyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum willd. International Journal of Green Pharmacy. 209-211.

Niarakis, A., Ostaszewski, M., Mazein, A., Kuperstein, I., Kutmon, Rex, D.A.B., Orlic-Milacic., Auffray, C., Balling, R. and Schneider, R. (2022) 'A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms'. Submitted
Singh, N., Munjal, A., Kumari, G., Kaushik, S., Kahlon, A.K., Gupta, S., Chaurasiya, A., Anam, Z-e., Maurya, M.K., Srivastava, P., Singhal, J., Marothia, M., Joshi, P., Jain, R., Rex, D.A.B., Prasad, T.S., Mundae, M., Malhotra, P., Ranganathan, A., & Singh, S. (2023). Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection. Submitted
Dagamajalu, S., Najar, M. A., Rex, D. A. B., Modi, P. K., Suchitha G. P., Chandrasekaran, J., and Prasad, T. S. K. Identifying molecular targets conferred by Annona muricata L. (A. muricata) leaf extract in oral adenosquamous carcinoma cells (OSCC) by using a phosphoproteomic approach. Submitted
Keerthi, G. P., Kirthika, G., Rex, D.A.B., Saptami, K., Parasuram, P., Jaikanth, C. (2023). Computational design of Novel Casein kinase 2 small molecule inhibitors for cancer therapy. Submitted
Jaikanth, C., Saptami, K., Shobha, D., Prasad, T.K., Rex, D.A.B. (2023). Computational design of Checkpoint Kinase-1 (CHK-1) inhibitors for cancer therapy. Submitted (Corresponding author).
Suchitha G. P., Dagamajalu, S*. A., Raju, R., Kandasamy, R. K., Prasad, T.K., Rex, D.A.B*. (2023). A network map of IL-26 signaling pathway. Submitted. (*Shared corresponding author)
Thatai, A.K.S*., Ammankallu, S*., Rex, D.A.B*., Soman, S.P., Nisar, M., George, A., Anto, C.K., Sanjeev, D., Kandiyil, M.K., John, L., Raj, S.S., Awasthi, K., Vinodchandra, S.S., Prasad, T.S.K., & Raju, R. (2023). VirhostlncR: A comprehensive database for molecular targets of lncRNAs in viral infections. Submitted (*Shared first author)
Aravind, A., Nisar, M., Nandakumar, R., Palollathil, A., Kanichery, A., Rex, D.A.B., Prasad, T.S.K., Vijayakumar, M., & Raju, R. (2023). REMEMProt: A resource of experimental-membrane-enriched mass spectrometry-derived proteome. Submitted
Suchitha, G. P., Pervaje, R., Modi, P. K., Prabhu, A., Rex, D.A.B., Prasad, K. T. S., & Dagamajalu, S. (2023). Anticancer activity of Bhallataka taila via prevention of EMT through the modulation of AKT/mTOR pathway in lung adenocarcinoma cells. Submitted.
Phukan, H., Sarma, A., Rex, D. A. B., Christie, S., K S, S., Hariharan, S., Prasad, T. S. K., & Madanan, M. (2023). Physiological Temperature and Osmotic Changes Drive Dynamic Proteome Alterations in Leptospiral Outer Membrane and Enhance Protein Export Systems. Submitted

Portfolio

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Rex Devasahayam Arokia Balaya, MPhil., Ph.D.

About Me

Post Doctoral Research Fellow

Facts

Skills

Resume

Sumary

Rex Devasahayam Arokia Balaya

Education

Ph.D. in Biochemistry

2017 - 2022

M.Phil. in Biochemistry

2010 - 2012

M.Sc. in Biochemistry

2007 - 2009

Diploma in Bioinformatics

2007 - 2008

B.Sc in Biochemistry

2004 - 2007

Professional Experience

Post Doctoral Research Fellow

2023 - Present

Assistant Professor

2022 - 2023

Ph.D. student

2016-2022

Project fellow

2015-2016

Project Fellow

2014-2015

Technical Skills (Cell and Molecular Biology)

Proteomics and Protein Biochemistry

Proteogenomics

Signaling pathways

Molecular biology and cell culture

Proteomics Software

LC-MS

Top 10 Publications

Publications

1. Sanjeev, D., Dagamajalu, S*., Shaji, V., George, Subbannayya, Y., M., Prasad, T. S. K., Raju, R*., Rex, D. A. B*. (2023). A network map of MSP signaling pathway. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)

2. Upadhyay, S. S., Rex, D. A. B*., Parate, S. S., Dagamajalu, S., Prasad, T. S. K*., Shetty, R*., Raju, R*. (2023). An assembly of TROP2-mediated signaling events. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)

3. Chandrasekaran, J., Parasuraman, P., Krishnan, S., Rex, D. A. B., Kunjiappan, S. (2023). Prospects for repurposing FDA-approved medications as Omicron spike/ACE-2 protein complex disruptors. Journal of Research in Pharmacy.

4. Suchitha G. P., Rex, D.A.B*., Raju, R., Prasad, T.K., Dagamajalu, S. A. (2023). network map of Cytoskeleton-associated protein 4 (CKAP4)-mediated signaling pathway in cancer. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)

9. Rex, D. A. B*., Kanekar, S*., Chanderasekaran, J., Rekha, P. D. Pleotropic potential of quorum sensing mediated N-acyl homoserine lactones (AHLs) at the LasR and RhlR receptors of Pseudomonas aeruginosa. Molecular Diversity. (Impact factor: 3.364) (Shared first author)

14. Rex, D. A. B., Prasad, T. S. K., Kandasamy, R. K. (2022). Revisiting Regulated Cell Death Responses in Viral Infection. International Journal of Molecular Sciences. (Impact Factor: 6.208)

16. Kanekar, S., Rex, D. A. B., Chanderasekaran, J., Rekha, P. D. (2022). Competitive interaction of thymol with cviR inhibits quorum sensing and associated biofilm formation in Chromobacterium violaceum. International Microbiology. (Impact factor: 3.097)

17. Rex, D. A. B., Vaid, N., K. Deepak, K., Dagamajalu, S., Prasad, T. S. K. (2022). A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases. Molecular Biology Reports. (Impact factor: 2.741)

20. Rex, D. A. B., Suchitha G. P., Palollathil, A., Kanichery, A., Prasad, T. S. K. and Dagamajalu, S. (2022). The network map of Urotensin-II mediated signaling pathway in physiological and pathological conditions. Journal of Cell Communication and Signaling. (Impact factor: 5.9)

24. Rex, D. A. B., Dagamajalu, S., Raju, R., Kandasamy, R. K. and Prasad, T. S. K. (2021). SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanism in COVID-19. Journal of Cell Communication and Signaling. 15, 601-608. PMID: 34181169. (Impact factor 5.9)

27. Rex, D. A. B., K. Deepak, K., Vaid, N., Dagamajalu, S., Kandasamy, R. K., Flo, T. H. and Prasad, T. S. K. (2021). A modular map of Bradykinin-mediated inflammatory signaling network. Journal of Cell Communication and Signaling. Oct 29:1–10. PMID: 34714516. (Impact factor 5.9)

28. Dagamajalu, S., Vijayakumar, M., Shetty, R., Rex, D. A. B., Narayana Kotimoole, C. and Prasad, T. S. K. (2020). Proteogenomic examination of esophageal squamous cell carcinoma (ESCC): new lines of inquiry. Expert Review of Proteomics. Sep;17(9):649-662. PMID: 33151123. (Impact factor: 4.2)

31. Rex, D. A. B., Agarwal, N., Prasad, T. S. K., Kandasamy, R. K., Subbannayya, Y. and Pinto, S. M. (2020). A comprehensive pathway map of IL-18-mediated signalling. Journal of Cell Communication and Signaling. Jun;14(2):257-266. PMID: 31863285. (Impact factor: 5.9)

33. Dagamajalu, S., Rex, D. A. B., Suchitha G. P., Rai, B. A., Rainey, J. K., and Prasad, T. S. K. (2021). The network map of Elabela signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2, 1-0. PMID: 34339006. (Impact factor: 5.9)

36. Rex, D. A. B., Kumar, S. T. A., Modi, P. K. and Prasad, T. S. K. (2021). Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe or Promising Molecular Target? OMICS: A Journal of Integrative Biology. 25, 408-416. PMID: 34191617. (Impact factor: 3.973)

39. Dagamajalu, S*., Rex, D. A. B*., Palollathil, A., Shetty, R., Bhat, G., Cheung, L.W.T. and Prasad, T. S. K. (2021). A pathway map of AXL receptor-mediated signaling network. Journal of Cell Communication and Signaling. 15, 143-148. PMID: 32829427. (Impact factor: 5.9). * Shared first author

40. Dagamajalu, S*., Rex, D. A. B*., Philem, P. D., Rainey, J. K., and Prasad, T. S. K. (2021). A network map of apelin- mediated signaling. Journal of cell communication and signaling. 16, 137-143. PMID: 33797707. (Impact factor: 5.9). * Shared first author

43. Pinto, S. M., Subbannayya, Y., Rex, D. A. B., Raju, R., Chatterjee, O., Advani, J., Radhakrishnan, A., Prasad, T. S. K., Wani, M. R. and Pandey, A. (2018). A network map of IL-33 signaling pathway. Journal of Cell Communication and Signaling. 12, 615-624. PMID: 29705949. (Impact factor: 5.9)

44. Rex, D. A. B., Kumar, RR. (2014). The Role of Nanotechnology in Targeting Carcinogens-A Comparison on Synthesis of Gold and Zinc Nanoparticles. Journal of Biomaterials and Tissue Engineering. 4 (8), 591-599. (Impact factor: 0.144)

45. Rex, D. A. B. (2014). Selenium enriched mushrooms as a food supplement for prevention of neurodegenerative diseases. Int J Pharm Pharm Sci, 6, 1-2.

46. Karthikeyan, A., Siva, G., Sujitha, SP., Rex, D. A. B., Chidambaranathan, N. (2008). Antihyperglycemic activity of the ethanolic seed extract of Vernonia anthelminticum willd. International Journal of Green Pharmacy. 209-211.

Niarakis, A., Ostaszewski, M., Mazein, A., Kuperstein, I., Kutmon, Rex, D.A.B., Orlic-Milacic., Auffray, C., Balling, R. and Schneider, R. (2022) 'A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms'. Submitted

Dagamajalu, S., Najar, M. A., Rex, D. A. B., Modi, P. K., Suchitha G. P., Chandrasekaran, J., and Prasad, T. S. K. Identifying molecular targets conferred by Annona muricata L. (A. muricata) leaf extract in oral adenosquamous carcinoma cells (OSCC) by using a phosphoproteomic approach. Submitted

Keerthi, G. P., Kirthika, G., Rex, D.A.B., Saptami, K., Parasuram, P., Jaikanth, C. (2023). Computational design of Novel Casein kinase 2 small molecule inhibitors for cancer therapy. Submitted

Jaikanth, C., Saptami, K., Shobha, D., Prasad, T.K., Rex, D.A.B. (2023). Computational design of Checkpoint Kinase-1 (CHK-1) inhibitors for cancer therapy. Submitted (Corresponding author).

Suchitha G. P., Dagamajalu, S*. A., Raju, R., Kandasamy, R. K., Prasad, T.K., Rex, D.A.B*. (2023). A network map of IL-26 signaling pathway. Submitted. (*Shared corresponding author)

Aravind, A., Nisar, M., Nandakumar, R., Palollathil, A., Kanichery, A., Rex, D.A.B., Prasad, T.S.K., Vijayakumar, M., & Raju, R. (2023). REMEMProt: A resource of experimental-membrane-enriched mass spectrometry-derived proteome. Submitted

Suchitha, G. P., Pervaje, R., Modi, P. K., Prabhu, A., Rex, D.A.B., Prasad, K. T. S., & Dagamajalu, S. (2023). Anticancer activity of Bhallataka taila via prevention of EMT through the modulation of AKT/mTOR pathway in lung adenocarcinoma cells. Submitted.

Phukan, H., Sarma, A., Rex, D. A. B., Christie, S., K S, S., Hariharan, S., Prasad, T. S. K., & Madanan, M. (2023). Physiological Temperature and Osmotic Changes Drive Dynamic Proteome Alterations in Leptospiral Outer Membrane and Enhance Protein Export Systems. Submitted

1. Rex, D. A. B., T. S. Keshava Prasad. (2022). Data analysis pipelines, potential pitfalls, and troubleshooting for MS-based biomarker discovery and validation. Protein Biomarkers: Discovery and Applications in Clinical Diagnostics. Springer Nature. (Under review)

1. Prasad, T. S. K., Rex, D. A. B., Kumar, S. T. A., “Composition for wound healing” Indian patent, 2023. No: 202141036627

Portfolio

Molecular biology and cell
culture

1. Sanjeev, D., Dagamajalu, S., Shaji, V., George, Subbannayya, Y., M., Prasad, T. S. K., Raju, R., Rex, D. A. B. (2023). A network map of MSP signaling pathway. Journal of Cell Communication and Signaling. (Impact factor 5.9) (Shared corresponding author)

2. Upadhyay, S. S., Rex, D. A. B., Parate, S. S., Dagamajalu, S., Prasad, T. S. K., Shetty, R., Raju, R. (2023). An assembly of TROP2-mediated signaling events. Journal of Cell Communication and Signaling. (Impact factor 5.9) (*Shared corresponding author)

4. Suchitha G. P., Rex, D.A.B., Raju, R., Prasad, T.K., Dagamajalu, S. A. (2023). network map of Cytoskeleton-associated protein 4 (CKAP4)-mediated signaling pathway in cancer. Journal of Cell Communication and Signaling. (Impact factor 5.9) (Shared corresponding author)

9. Rex, D. A. B., Kanekar, S., Chanderasekaran, J., Rekha, P. D. Pleotropic potential of quorum sensing mediated N-acyl homoserine lactones (AHLs) at the LasR and RhlR receptors of Pseudomonas aeruginosa. Molecular Diversity. (Impact factor: 3.364) (Shared first author)

39. Dagamajalu, S., Rex, D. A. B., Palollathil, A., Shetty, R., Bhat, G., Cheung, L.W.T. and Prasad, T. S. K. (2021). A pathway map of AXL receptor-mediated signaling network. Journal of Cell Communication and Signaling. 15, 143-148. PMID: 32829427. (Impact factor: 5.9). * Shared first author

40. Dagamajalu, S., Rex, D. A. B., Philem, P. D., Rainey, J. K., and Prasad, T. S. K. (2021). A network map of apelin- mediated signaling. Journal of cell communication and signaling. 16, 137-143. PMID: 33797707. (Impact factor: 5.9). * Shared first author

Suchitha G. P., Dagamajalu, S. A., Raju, R., Kandasamy, R. K., Prasad, T.K., Rex, D.A.B. (2023). A network map of IL-26 signaling pathway. Submitted. (*Shared corresponding author)